Ethan Wickens
Retinal axon pathfinding: cellular events controlled by subcellular compartment-restricted second messengers
I joined the Institute De La vision, in Paris, at the beginning of October. I am working under the supervision of Xavier Nicol and Coralie Fassier.
Personal Background and Interest
I am keenly interested in the interdisciplinary nature of biological research, especially as it relates to disease. My current project will be drawing from areas of cell biology, developmental neuroscience, optogenetics and microscopy. This research will aim to inform the development of regenerative therapies for glaucoma.
I have a background in structural biology, studying Parkinson’s disease. I am, therefore, excited to apply myself to the field of cell biology and microscopy within the lab. I hope to contribute valuable skills gained from my previous research, to this current project.
Aim of the project
My project aims to understand vesicular trafficking events controlled by subcellular compartment-restricted second messengers and how these enable the axonal pathfinding of Retinal Ganglion Cells (RGCs). The pathfinding of RGCs enables suitable connectivity and development of the mature visual system. By developing our understanding of these processes, we hope to inform the development of regenerative therapies for Glaucoma.
Current activities/Accomplishments
Starting this project, I developed my confidence with cell culture techniques, and the use of microscopes within the lab. I have now recently begun visualization, and tracking, of a specific vesicle population in the developing axon and growth cone. I am now excited to begin designing experiments to understand the role of vesicles in axonal pathfinding and to start characterizing how their dynamics are regulated by specific subcellular compartment-restricted second messengers.